Inclusion Body Hepatitis (IBH) is a significant viral disease caused by fowl adenoviruses, primarily affecting chickens. The disease typically presents with a sudden onset and can lead to increased mortality rates. Infected birds often exhibit symptoms such as depression, ruffled feathers, and jaundice. Pathologically, IBH is characterized by notable liver lesions, where the liver appears pale and swollen with necrotic areas, and hepatocytes contain basophilic inclusion bodies. Transmission of the virus occurs through direct contact with infected birds, contaminated equipment, and potentially vertical transmission from hen to egg. Effective management of IBH involves stringent biosecurity measures, maintaining proper hygiene, and implementing vaccination programs when available, including the use of autogenous vaccines tailored to local viral strains.